-transparent.png){kind=logo}
For the oxyntic cell of the stomach the hypothesis was forwarded by Grossmann and Konturek [1] that, if one of its three receptors is blocked, the physico-chemical properties of the two others are changed in such a way that they respond less sensitively to their specific stimulation. This hypothesis was tested for the heart by studying the effect of histamine-H2-receptor- and beta-receptor-blockade on the orciprenaline-, histamine-, and prostaglandin E1-stimulated frequency of the spontaneously beating isolated guinea-pig atrium. Therefore cumulative dose response curves were established for orciprenaline, histamine and prostaglandin E1 (PGE1) alone or in the presence of metiamide or pindolol. (1) The beta-blocker pindolol inhibited the effect of orciprenaline in a competitive manner, without having an effect on histamine- and PGE1-stimulation. (2) The histamine H2-receptor blocker metiamide inhibited the histamine response competitively. (3) In contrast to pindolol, metiamide inhibited the PGE1-stimulated rise in atrial frequency, most obviously non- or uncompetitively. From these results it is evident that in the heart the particular inhibitors, at least at the receptor site, act rather specifically without affecting neighbouring receptors and that metiamide influences the PGE1-response in a way different from the receptor site.
K Süsskand, and
M Siess, and
K F Sewing
January 1982,
Pharmacology,
K Süsskand, and
M Siess, and
K F Sewing
August 1990,
Agents and actions,
K Süsskand, and
M Siess, and
K F Sewing
January 1967,
Helvetica physiologica et pharmacologica acta,
K Süsskand, and
M Siess, and
K F Sewing
January 1986,
General pharmacology,
K Süsskand, and
M Siess, and
K F Sewing
January 1986,
British journal of pharmacology,
K Süsskand, and
M Siess, and
K F Sewing
December 1975,
West African journal of pharmacology and drug research,
K Süsskand, and
M Siess, and
K F Sewing
January 1999,
Fundamental & clinical pharmacology,
K Süsskand, and
M Siess, and
K F Sewing
January 1982,
Archives internationales de pharmacodynamie et de therapie,
K Süsskand, and
M Siess, and
K F Sewing
June 1978,
Research communications in chemical pathology and pharmacology,
K Süsskand, and
M Siess, and
K F Sewing
December 1979,
Archives internationales de pharmacodynamie et de therapie,
