Experimental and clinical studies of 5-fluorocytosine activity in candida ocular infections, II. The effect of 5-fluorocytosine in treating experimental candida infection in rabbits' eyes. 1975

E Segal, and A Romano, and E Eylan, and R Stein

Mild and severe experimental ocular infections in rabbits' eyes were induced by inoculation of Candida albicans with or without addition of dexamycin drops. These rabbits were treated with 5-Fluorocytosine, topically, orally and in a combined topical and oral manner. The topical treatment was effective only in mild infections. Severe infections responded to oral and especially to combined oral-tropical treatment.

UI MeSH Term Description Entries
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002177 Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed) Candida Infection,Moniliasis,Candida Infections,Candidiases,Infection, Candida,Moniliases
D003596 Cytosine A pyrimidine base that is a fundamental unit of nucleic acids.
D005128 Eye Diseases Diseases affecting the eye. Eye Disorders,Eye Disease,Eye Disorder
D005437 Flucytosine A fluorinated cytosine analog that is used as an antifungal agent. 5-Fluorocytosine,Alcobon,Ancobon,Ancotil
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000287 Administration, Topical The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example. Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

E Segal, and A Romano, and E Eylan, and R Stein
September 1979, Antimicrobial agents and chemotherapy,
E Segal, and A Romano, and E Eylan, and R Stein
January 1970, Transactions of the ophthalmological societies of the United Kingdom,
E Segal, and A Romano, and E Eylan, and R Stein
July 1974, The Journal of infectious diseases,
E Segal, and A Romano, and E Eylan, and R Stein
May 1969, Applied microbiology,
E Segal, and A Romano, and E Eylan, and R Stein
February 1987, Archives of ophthalmology (Chicago, Ill. : 1960),
E Segal, and A Romano, and E Eylan, and R Stein
October 1965, Bulletin of the Calcutta School of Tropical Medicine,
E Segal, and A Romano, and E Eylan, and R Stein
February 1992, The Journal of antimicrobial chemotherapy,
E Segal, and A Romano, and E Eylan, and R Stein
February 1987, Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
E Segal, and A Romano, and E Eylan, and R Stein
November 1976, Modern medicine of Asia,
E Segal, and A Romano, and E Eylan, and R Stein
October 1969, Nippon Ganka Gakkai zasshi,
Copied contents to your clipboard!