-transparent.png){kind=logo}
The pattern of human growth hormone (HGH) release was studied in depressed patients during sleep under EEG control and employing high temperature exposure. The patients were free of drugs and were compared with corresponding control groups. In the sleep study (6 depressed patients), 2 patients showed no definite increase in HGH plasma concentration, and 3 patients showed an increase in HGH only in the second half of the night, independent of slow wave sleep (SWS). But sleep disturbances were present in all 5 patients. A correlation between SWS and HGH release was found in only 1 patient. One nondepressed control, without SWS, showed a delayed HGH response. Exposure to high temperature in normal subjects induced an acute HGH release. 8 of the 13 patients studied had a deficient HGH RESPONSE. All were depressive, with psycho motor retardation and marked vital and neurovegetative disturbances. These findings support the idea that, at least in a high percentage of depressed patients, there is a disturbance of the hypothalamic pituitary function.
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
April 1998,
Progress in neuro-psychopharmacology & biological psychiatry,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
July 1973,
Archives of disease in childhood,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
June 1969,
The Journal of clinical endocrinology and metabolism,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
February 1985,
Endocrinologia japonica,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
January 1985,
Acta psychiatrica Belgica,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
January 1982,
Sleep,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
June 1978,
Archives of disease in childhood,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
July 1973,
Research communications in chemical pathology and pharmacology,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
December 2002,
Journal of affective disorders,
R Schilkrut, and
O Chandra, and
M Osswald, and
E Rüther, and
B Baafüsser, and
Matussek
January 1977,
Psychoneuroendocrinology,
