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Twenty-six week carcinogenicity study of ampicillin in CB6F1-TgrasH2 mice. 2002
Tamiko Adachi, and
Yuki Kuwamura, and
Toshihisa Fujiwara, and
Noriaki Tanimoto, and
Tomonari Nishimura, and
Atsushi Koguchi, and
Kinji Kobayashi, and
Yoshifumi Sasaki, and
Chisato Yamaguchi, and
Tatsuya Honda, and
Kazutaka Kawashima, and
Hirofumi Yuasa, and
Takaaki Yamamura, and
Toshihide Inui
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan.
As a part of the ILSI-HESI Alternative to Carcinogenicity Testing (ACT) program, we performed a 26-week carcinogenetic study of nonmutagenic drug, ampicillin (ABPC) in Tg-rasH2 mice. ABPC was given to Tg-rasH2 mice (0, 350, 1000, 3000 mg/kg, p.o.) and Non-Tg mice (0, 3000 mg/kg, p.o.) daily for 26 weeks. As a positive control, a single dose of MNU was administered once to Tg-rasH2 mice (75 mg/kg, i.p.). In this study, Tg-rasH2 mice did not demonstrate any increases in tumor development in response to ABPC. Thus, ABPC had no carcinogenicity in the 26-week carcinogenesis study in Tg-rasH2 mice or in a 2-year carcinogenesis study in B6C3F1 mice.
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