BIOMAT Database Logo BIOMAT Database Logo

Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. 1975

H Ohno, and T Ohno, and J Awaya, and S Omura

Cerulenin, a specific inhibitor of beta-ketoacyl-(acyl carrier protein) synthetase [EC 2.3.1.41] and 3-hydroxy-3-methylglutaryl-CoA synthetase [EC 4.1.3.5], was studied to determine whether it inhibits 6-methylsalicylic acid synthesis, in which so-called "polyketide" formation, a condensation step similar to that in fatty acid synthesis, is involved. In fact, 100 mug/ml (4.5 X 10(-4) M) of cerulenin inhibited 60% of 6-methylsalicylic acid synthetase activity and 68% of fatty acid synthetase activity of Penicillium urticae.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D010407 Penicillium A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin. Penicilliums
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D002569 Cerulenin An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function. 2,3-Epoxy-4-oxo-7,10-dodecadienoylamide
D000217 Acyltransferases Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3. Acyltransferase
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D012459 Salicylates The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis. Salicylate,Salicylic Acids,Acids, Salicylic
D015099 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41. 3 Oxoacyl (Acyl Carrier Protein) Synthase,3-Keto-ACP Synthase,3-Oxoacyl (Acyl Carrier Protein) Synthase,3-Oxoacyl Synthetase,Acyl-Malonyl-ACP Condensing Enzyme,beta Keto Acyl Synthetase,beta Keto-Acyl Carrier Protein Synthase I,beta Keto-Acyl Carrier Protein Synthase II,beta Ketoacyl ACP Synthase,beta-Ketoacyl-Coenzyme A (CoA) Synthase,3 Keto ACP Synthase,3 Oxoacyl Synthetase,Acyl Malonyl ACP Condensing Enzyme,Condensing Enzyme, Acyl-Malonyl-ACP,Synthase, 3-Keto-ACP,Synthetase, 3-Oxoacyl,beta Keto Acyl Carrier Protein Synthase I,beta Keto Acyl Carrier Protein Synthase II
D064429 Fatty Acid Synthases Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives. Fatty Acid Synthase,Fatty Acid Synthetases,Acid Synthase, Fatty,Acid Synthases, Fatty,Synthase, Fatty Acid,Synthetases, Fatty Acid

Related Publications

H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of fatty acid synthetases by the antibiotic cerulenin.
August 1972, Biochemical and biophysical research communications,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of unsaturated fatty acid synthesis in escherichia coli by the antibiotic cerulenin.
November 1978, Biochemistry,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of lipid synthesis in Escherichia coli cells by the antibiotic cerulenin.
May 1973, Antimicrobial agents and chemotherapy,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase.
November 1973, Biochimica et biophysica acta,
H Ohno, and T Ohno, and J Awaya, and S Omura
Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast.
April 1974, Biochemical and biophysical research communications,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin.
March 1992, Applied and environmental microbiology,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of the biosynthesis of leucomycin, a macrolide antibiotic, by cerulenin.
January 1974, Journal of biochemistry,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of the biosynthesis of leucomycin, a macrolide antibiotic, by cerulenin.
April 1977, Journal of biochemistry,
H Ohno, and T Ohno, and J Awaya, and S Omura
Inhibition of de novo fatty acid synthesis by the antibiotic cerulenin in Bacillus subtilis: effects on citrate-Mg2+ transport and synthesis of macromolecules.
September 1975, Antimicrobial agents and chemotherapy,
H Ohno, and T Ohno, and J Awaya, and S Omura
Growth inhibition of Halobacterium cutirubrum by cerulenin, a potent inhibitor of fatty acid synthesis.
September 1977, Biochemical and biophysical research communications,
Copied contents to your clipboard!