Small airways disease in coal miners. A longitudinal study. 1975

D R Hall, and N L Lapp, and R Reger, and A Seaton

Seventeen of an original cohort of 25 non-smoking working coal miners and 6 age-matched controls studied in 1969 were re-examined in 1973. Measurements included lung volumes, maximal expiratory flow-volume curves, and closing volumes. Miners, when compared with controls, showed a marked decline in maximal expiratory flow at mid-vital capacity (V 50%) over the 4-year period which took place without significant change in the 1-second forced expiratory volume (FEV1). Frequency dependence of dynamic compliance (Cdyn) in association with an increased upstream airways resistance (Rus), and also loss of lung elastic recoil (PL(St)) which were present at the time of the original study led to similar declines in V 50%. An abnormally elevated closing capacity expressed as a percentage of total lung capacity (CC/TLC)% was found in 9 miners (53%) and none of the controls. Closing volume as a percentage of vital capacity (CV/VC)% was abnormal in 4 miners (23.5)% and no controls. Measurement of closing volume did not relate well to the variety of mechanical abnormality present on the original study; namely, loss of recoil or small airways obstruction. The presence of an elevated (CC/TLC)% and (CV/VC)% correlated mainly with the presence of hyperinflation as indicated by an elevated residual volume.

UI MeSH Term Description Entries
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008170 Lung Compliance The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562) Compliance, Lung,Compliances, Lung,Lung Compliances
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008906 Mining The process of extracting mineral deposits from the earth.
D011009 Pneumoconiosis A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population. Bagassosis,Pneumoconioses
D012115 Residual Volume The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV. Residual Volumes,Volume, Residual,Volumes, Residual
D012123 Pulmonary Ventilation The total volume of gas inspired or expired per unit of time, usually measured in liters per minute. Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory

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