[Pathogenesis of disorders of cardiac rhythm and conductivity in acute organophasphate insecticide poisoning]. 1975

E A Lyzhnikov, and A S Savina, and V M Shepelev

A dynamic examination of ECG and K and Na level in plasma and erythrocyte was conducted in 73 patients during the acute period of poisoning with phosphorus-organic insecticides -- thiophos, chlorophos, carbophos. In 18.6% of the cases severe rhythm and conductivity disorders were revealed that caused cardiac arrest and death in 29 patients. Besides, a sharp increase in the electric systole on the ECG was noted in all the patients during the acute period of poisoning. A study of the electrolytes revealed hypokalemia, hypernatremia and an increased content of K and Na in the erythrocytes. The authors believe that the disturbances in the cardiac activity during acute poisonings with phosphorus-organic insecticides are due to the effect of the excessive acetylcholine upon the ion permeability towards increasing intracellular potassium.

UI MeSH Term Description Entries
D006955 Hypernatremia Excessive amount of sodium in the blood. (Dorland, 27th ed) Hypernatremias
D007008 Hypokalemia Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed) Hypopotassemia,Hypokalemias,Hypopotassemias
D007306 Insecticides Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. Insecticide
D008297 Male Males
D009943 Organophosphorus Compounds Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS. Organophosphorus Compound,Organopyrophosphorus Compound,Organopyrophosphorus Compounds,Compound, Organophosphorus,Compound, Organopyrophosphorus,Compounds, Organophosphorus,Compounds, Organopyrophosphorus
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002802 Cholinesterases Acylcholineacylhydrolase,Cholase,Cholinesterase
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute

Related Publications

E A Lyzhnikov, and A S Savina, and V M Shepelev
November 1981, Vrachebnoe delo,
E A Lyzhnikov, and A S Savina, and V M Shepelev
August 1960, Klinicheskaia meditsina,
E A Lyzhnikov, and A S Savina, and V M Shepelev
January 2000, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
E A Lyzhnikov, and A S Savina, and V M Shepelev
April 1959, Revue medicale de la Suisse romande,
E A Lyzhnikov, and A S Savina, and V M Shepelev
June 1978, ZFA. Zeitschrift fur Allgemeinmedizin,
E A Lyzhnikov, and A S Savina, and V M Shepelev
April 1968, Coeur et medecine interne,
E A Lyzhnikov, and A S Savina, and V M Shepelev
April 1969, Terapevticheskii arkhiv,
E A Lyzhnikov, and A S Savina, and V M Shepelev
January 1980, Terapevticheskii arkhiv,
E A Lyzhnikov, and A S Savina, and V M Shepelev
September 1978, Sovetskaia meditsina,
Copied contents to your clipboard!