Biomaterial Database

[Gaschromatographic examination of the expired air after anaesthesia with halothane, enflurane and methoxyflurane (author's transl)]. 1975

P H Klan, and H N Herden, and P Lawin

The concentration of anaesthetic gases in the expired air was studied for up to 17 days in patients who had been anaesthetized with methoxyflurane, enflurane or halothane. The estimation were made by means of gaschromatography. The rate and duration of elimination of the anaesthetic via the lungs depends on the fat stores of the patient (as calculated by the body weight/stature ratio), the length of anaesthesia and the Lutz index (calculated average concentration of the inhaled anaesthetic). The concentration of anaesthetic gases in the expired air fell steeply during the first 12 hours after anaesthetic and then decreased more gradually. The drop in concentration during the first 24 hours was steepest for methoxyflurane, followed by halothane and enflurane in that order. The results are in fair agreement with the rate of metabolization of the three anaesthetic agents. The investigation showed that during the first after anaesthesia appreciable quantities of anaesthetic gases are eliminated via the lungs and, consequently, released into the air of the recovery room.

UI	MeSH Term	Description	Entries
D008733	Methoxyflurane	An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)	Methofluranum,Anecotan,Penthrane,Pentrane
D008738	Methyl Ethers	A group of compounds that contain the general formula R-OCH3.	Ethers, Methyl
D002849	Chromatography, Gas	Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.	Chromatography, Gas-Liquid,Gas Chromatography,Chromatographies, Gas,Chromatographies, Gas-Liquid,Chromatography, Gas Liquid,Gas Chromatographies,Gas-Liquid Chromatographies,Gas-Liquid Chromatography
D004737	Enflurane	An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.	Alyrane,Enfran,Enlirane,Ethrane,Etran
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor