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The content and hydrophobic properties (distribution coefficient in hexan : water) of organophosphorus inhibitors OPT of the following structure--R-O (CH3)/P/O/S C2H4SC2H5 have been studied in rat brain. On enlargement of the O-alkyl radical from ethyl to isopropyl and pinacolin hydrophobecity increases from 1 to 12 and 39, while the relative content of the chloroform extractable free OPT in brain, under conditions of uniform distribution, decreases from 11--18% to 3.2%. On incubation of the homogenate at 37 degrees C the further inhibition of the specific cholinesterase of the brain indicates the presence of an absolutely free form of OPT, the amount of which is not dependent on the degree of its hydrophobicity.
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1970,
Voprosy meditsinskoi khimii,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1976,
Biulleten' eksperimental'noi biologii i meditsiny,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1976,
Ukrains'kyi biokhimichnyi zhurnal,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
November 1972,
Biulleten' eksperimental'noi biologii i meditsiny,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1973,
Eksperimentalna meditsina i morfologiia,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1970,
Biokhimiia (Moscow, Russia),
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1977,
Tsitologiia,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
November 1972,
Arzneimittel-Forschung,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1975,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
E K Balashova, and
D L Pevzner, and
V I Rozengart, and
O E Sherstobitov, and
A A Abduvakhobov
January 1968,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
