BIOMAT Database Logo BIOMAT Database Logo

Histopathologic features of genetically determined ovarian cancer. 2002

P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Department of Pathology, University Health Network, University of Toronto, ON, Canada.

Inheritance of germline mutations of BRCA1 or BRCA2 genes account for approximately 10% of ovarian carcinomas, but the characterization of these genetically determined cancers is incomplete. The objective of our study was to characterize the histologic features of ovarian carcinomas associated with germline mutations of BRCA1 and BRCA2. Thirty-two ovarian carcinomas associated with germline BRCA1 or BRCA2 mutations and 40 ovarian carcinomas from patients screened as negative for germline mutations were obtained from three centers. A gynecologic pathologist, blinded to mutation status, reviewed each case, with documentation of the histologic type, Gynecologic Oncology Group (GOG) grade, architectural and nuclear grade, Silverberg grade, and mitotic activity. All BRCA1 and BRCA2 mutation-associated cases were invasive serous carcinomas, and of these 50% were GOG grade 3, 41% had an architectural grade of 3 (predominant solid architecture), 84% a nuclear grade of 3, 72% a mitotic score of 3 (>25 mitoses per 10 HPF), and 75% a Silverberg grade of 3. The differences in histologic type (p = 0.001) and Silverberg grade (p = 0.002) between these tumors and the control group were statistically significant and remained so when comparisons between BRCA carriers and noncarriers were restricted to carcinomas of serous histology alone. Ovarian carcinomas associated with germline mutations of BRCA1/BRCA2 are, in this study, invasive serous carcinomas, with a statistically significant higher histologic grade than ovarian carcinomas without BRCA mutations when using the recently proposed Silverberg grading system.

UI MeSH Term Description Entries
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D018095 Germ-Line Mutation Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. Mutation, Germ-Line,Germline Mutation,Germ Line Mutation,Germ-Line Mutations,Germline Mutations,Mutation, Germ Line,Mutation, Germline,Mutations, Germ-Line,Mutations, Germline
D019398 Genes, BRCA1 A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. BRCA1 Gene,BRCA1 Genes,Gene, BRCA1
D020022 Genetic Predisposition to Disease A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. Genetic Predisposition,Genetic Susceptibility,Predisposition, Genetic,Susceptibility, Genetic,Genetic Predispositions,Genetic Susceptibilities,Predispositions, Genetic,Susceptibilities, Genetic
D024522 Genes, BRCA2 A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6) BRCA2 Gene,BRCA2 Genes,Gene, BRCA2

Related Publications

P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
A genetically determined ovarian dysfunction in mice.
December 1947, The Anatomical record,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Epidemiology of genetically determined cancer.
January 1989, Ciba Foundation symposium,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Genetically determined susceptibility to cancer.
September 1981, Blood,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Familial cancer: genetically determined? (review).
January 1983, Anticancer research,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Management of genetically determined colorectal cancer.
June 2019, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
[Methodological features of the detection of genetically determined muscular dystrophy].
January 1973, Revue roumaine de neurologie,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Tumour markers and histopathologic features of ovarian endometriotic cysts.
July 2021, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Peculiar histopathologic features of esophageal cancer.
January 1998, Surgery today,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
Ovarian clear cell carcinoma: an overview of key histopathologic features.
May 2023, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
P A Shaw, and J R McLaughlin, and R P Zweemer, and S A Narod, and H Risch, and R H M Verheijen, and A Ryan, and F H Menko, and P Kenemans, and I J Jacobs
MRI features of ovarian fibroma and fibrothecoma with histopathologic correlation.
March 2012, AJR. American journal of roentgenology,
Copied contents to your clipboard!