Biomaterial Database

Ethanol metabolism and liver oxidative capacity in cold acclimation. 1975

L Videla, and K V Flattery, and E A Sellers, and Y Israel

Exposure of rats to an ambient temperature of 5 degrees C for 4 to 6 weeks led to a 30 to 80 percent increase in the rate of oxygen consumption and a 50 percent increase in the rate of ethanol oxidation by liver slices, a 50 percent increase in mitochondrial alpha-glycerophosphate oxidase activity of liver, and a 100 percent increase in Na++K+-activated adenosine-triphosphatase, activity. Ouabain, an inhibitor of the Na++K+-activated adenosine-triphosphatase, completely blocked the extra respiration and ethanol oxidation. Dinitrophenol, which increases oxygen consumption and ethanol oxidation by liver slices from normal rats, was ineffective with slices from cold-exposed animals. Ethanol disappearance rate in vivo was also increased by cold acclimation, even though liver alcohol dehydrogenase activity was reduced. It is suggested that increased hydrolysis of ATP by the sodium pump system is responsible for the increased oxygen consumption and ethanol metabolism in the livers of cold-acclimated animals.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D010042	Ouabain	A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.	Acocantherin,G-Strophanthin,Acolongifloroside K,G Strophanthin
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D004140	Dinitrophenols	Organic compounds that contain two nitro groups attached to a phenol.
D005993	Glycerolphosphate Dehydrogenase		Alpha-Glycerophosphate Dehydrogenase,Glycerol-3-Phosphate Dehydrogenase,Glycerophosphate Dehydrogenase,Glycerophosphate Oxidase,Alpha Glycerophosphate Dehydrogenase,Dehydrogenase, Alpha-Glycerophosphate,Dehydrogenase, Glycerol-3-Phosphate,Dehydrogenase, Glycerolphosphate,Dehydrogenase, Glycerophosphate,Glycerol 3 Phosphate Dehydrogenase,Oxidase, Glycerophosphate