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Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome. 2002
Naoto T Ueno, and
Athanasios Anagnostopoulos, and
Gabriela Rondón, and
Richard E Champlin, and
N Mikhailova, and
O S Pankratova, and
L S Zoubarovskaya, and
E V Semenova, and
B V Afanasyev, and
Susan O'Brien, and
Michael Andreeff, and
Andrey Y Zaritskey
Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. nueno@mdanderson.org
In this report, we describe two patients with idiopathic hypereosinophilic syndrome (HES) who received a non-myeloablative allogeneic transplantation following a reduced-intensity preparative regimen of melphalan and fludarabine. In both cases, complete donor chimaerism and remission were achieved, and have lasted for more than 10 months. This report provides proof of principle for the feasibility of non-myeloablative transplantation for patients with idiopathic HES, who can show co-morbidity due to eosinophilic infiltration of their organs.
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