Abnormality in fibre type distribution of soleus and plantaris muscles in non-obese diabetic Goto-Kakizaki rats. 2002

Koichiro Yasuda, and Waka Nishikawa, and Nobumasa Iwanaka, and Eitaro Nakamura, and Yutaka Seino, and Kinsuke Tsuda, and Akihiko Ishihara
Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University, Kyoto, Japan. yasuda@tom.life.h.kyoto-u.ac.jp

1. Fibre type distributions of the slow soleus and fast plantaris muscles were investigated in 5-, 9- and 20-week-old male Goto-Kakizaki (GK) rats, as an animal model of non-obese diabetes, and were compared with those of age-matched non-diabetic Wistar rats. 2. Bodyweight and both soleus and plantaris muscle weights were lower in GK rats than in Wistar rats, regardless of age. In addition, both relative soleus and plantaris muscle weights per bodyweight were lower in GK rats than in Wistar rats, regardless of age. 3. In the soleus muscle, a higher percentage of type I fibres and a lower percentage of type IIA fibres were observed in 5- and 9-week-old GK rats. In addition, there were no type IIA fibres in 20-week-old GK rats. 4. In the plantaris muscle, there were no differences in fibre type distribution of 5-week-old GK rats. However, a higher percentage of type IIB fibres and a lower percentage of type I and type IIA fibres were observed in 9- and 20-week-old GK rats. In addition, there were no type I fibres in 20-week-old GK rats. 5. These results indicate that the decreased percentage of high-oxidative fibres (e.g. type IIA fibres in the soleus muscle and type I and type IIA fibres in the plantaris muscle) of the diabetic animals is concerned with an impairment in insulin sensitivity and glucose metabolism and is not related to bodyweight.

UI MeSH Term Description Entries
D008297 Male Males
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018482 Muscle, Skeletal A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles. Anterior Tibial Muscle,Gastrocnemius Muscle,Muscle, Voluntary,Plantaris Muscle,Skeletal Muscle,Soleus Muscle,Muscle, Anterior Tibial,Muscle, Gastrocnemius,Muscle, Plantaris,Muscle, Soleus,Muscles, Skeletal,Muscles, Voluntary,Skeletal Muscles,Tibial Muscle, Anterior,Voluntary Muscle,Voluntary Muscles
D018656 Muscle Fibers, Fast-Twitch Skeletal muscle fibers characterized by their expression of the Type II MYOSIN HEAVY CHAIN isoforms which have high ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Several fast types have been identified. Muscle Fibers, Intermediate,Muscle Fibers, Type II,Muscle Fibers, White,Fast-Twitch Muscle Fiber,Fast-Twitch Muscle Fibers,Fiber, Fast-Twitch Muscle,Fiber, Intermediate Muscle,Fiber, White Muscle,Fibers, Fast-Twitch Muscle,Fibers, Intermediate Muscle,Fibers, White Muscle,Intermediate Muscle Fiber,Intermediate Muscle Fibers,Muscle Fiber, Fast-Twitch,Muscle Fiber, Intermediate,Muscle Fiber, White,Muscle Fibers, Fast Twitch,White Muscle Fiber,White Muscle Fibers
D018657 Muscle Fibers, Slow-Twitch Skeletal muscle fibers characterized by their expression of the Type I MYOSIN HEAVY CHAIN isoforms which have low ATPase activity and effect several other functional properties - shortening velocity, power output, rate of tension redevelopment. Muscle Fibers, Red,Muscle Fibers, Type I,Fiber, Red Muscle,Fiber, Slow-Twitch Muscle,Fibers, Red Muscle,Fibers, Slow-Twitch Muscle,Muscle Fiber, Red,Muscle Fiber, Slow-Twitch,Muscle Fibers, Slow Twitch,Red Muscle Fiber,Red Muscle Fibers,Slow-Twitch Muscle Fiber,Slow-Twitch Muscle Fibers

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