Hepatitis G virus genotypes in a tertiary care centre in southern India. 2002

Priya Abraham, and Rachel Hallett, and Sujatha Radhakrishnan, and Sukanya Raghuraman, and Gopalan Sridharan, and Chong Gee Teo
Department of Clinical Virology, Christian Medical College Hospital, Vellore, India. apriya_98@yahoo.com

BACKGROUND The association of GBV-C/HGV in patients at high risk of parenteral infection and those with chronic liver disease in southern India is unknown. OBJECTIVE To study the occurrence of GBV-C/HGV in three patient groups attending a tertiary care centre in Vellore and identify the prevailing genotype(s). METHODS Two hundred and twenty-seven individuals were studied using an RT-PCR assay with primers specific for the 5'NCR and the NS5a-coding regions. Ten randomly selected samples were sequenced in the 5'NCR region of the GBV-C/HGV genome. RESULTS GBV-C/HGV RNA was detected in 37/70 (52.9%) of renal transplant recipients, 18/70 (25.7%) of patients with haematological disorders and in 9/87 (10.3%) patients with chronic liver disease. Nine of the ten sequences could be assigned to genotype 2a while the remaining sequence could not be assigned. CONCLUSIONS In this centre, GBV-C/HGV is widely prevalent in patients with high parenteral risk and in those with chronic liver disease. The predominantly circulating genotype among study patients is genotype 2a.

UI MeSH Term Description Entries
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D008107 Liver Diseases Pathological processes of the LIVER. Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006525 Hepatitis, Viral, Human INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D). Viral Hepatitis, Human,Human Viral Hepatitides,Human Viral Hepatitis,Viral Hepatitides, Human
D006760 Hospitalization The confinement of a patient in a hospital. Hospitalizations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012367 RNA, Viral Ribonucleic acid that makes up the genetic material of viruses. Viral RNA
D013789 Thalassemia A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia. Thalassemias
D015995 Prevalence The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. Period Prevalence,Point Prevalence,Period Prevalences,Point Prevalences,Prevalence, Period,Prevalence, Point,Prevalences

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