BIOMAT Database Logo BIOMAT Database Logo

[Simvastatin and extrinsic coagulation pathway in peritoneally dialyzed patients]. 2002

Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec

Peritoneally dialyzed subjects (CAPD) are prone to dyslipidemia and have a high risk of cardiovascular death. Statins (hydroxy-methylglutaryloCoA reductase inhibitors) show beneficial effects on serum lipids and hemostasis in kidney diseases. The purpose of this study was to assess platelet functions, some hemostatic parameters-extrinsic coagulation pathway-total, truncated, free TFPI (tissue factor pathway inhibitor), TF (tissue factor), TFPI/Xa and TF/VIIa complexes, as well as a marker of endothelial cell injury--von Willebrand factor--vWF and serum lipids in 10 hyperlipidemic CAPD patients treated with simvastatin (Zocor, MSD, at a dose of 10 mg at bedtime) for 3 months. Cholesterol and LDL fell significantly as early as after 1 month and remained lowered during further months of the therapy. No significant changes in von Willebrand factor, free TFPI, TF, TFPI/Xa and TF/VIIa complexes were found during therapy with simvastatin. Truncated TFPI decreased significantly as early as after 1 month and total TFPI decreased after 3 months of the therapy with simvastatin. Simvastatin is an effective hypolipemic agent. It seems that simvastatin have no or only little effect on endothelial function and extrinsic coagulation pathway in peritoneally dialyzed patients.

UI MeSH Term Description Entries
D006949 Hyperlipidemias Conditions with excess LIPIDS in the blood. Hyperlipemia,Hyperlipidemia,Lipemia,Lipidemia,Hyperlipemias,Lipemias,Lipidemias
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008074 Lipoproteins Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010531 Peritoneal Dialysis, Continuous Ambulatory Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution. CAPD,Continuous Ambulatory Peritoneal Dialysis
D010974 Platelet Aggregation The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS. Aggregation, Platelet
D001779 Blood Coagulation Factors Endogenous substances, usually proteins, that are involved in the blood coagulation process. Clotting Factor,Coagulation Factors,Blood Coagulation Factor,Clotting Factors,Coagulation Factor,Coagulation Factor, Blood,Coagulation Factors, Blood,Factor, Coagulation,Factors, Coagulation,Factor, Blood Coagulation,Factor, Clotting,Factors, Blood Coagulation,Factors, Clotting
D005167 Factor VII Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa. Coagulation Factor VII,Proconvertin,Stable Factor,Blood Coagulation Factor VII,Factor 7,Factor Seven,Factor VII, Coagulation
D005260 Female Females

Related Publications

Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
VAP-1 in peritoneally dialyzed patients.
December 2013, Postepy higieny i medycyny doswiadczalnej (Online),
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Increased soluble CD40L levels are reduced by long-term simvastatin treatment in peritoneally dialyzed patients.
September 2004, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Peripheral serotonergic system in hemodialyzed and peritoneally dialyzed patients.
November 2000, Nephron,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Management of peritoneally dialyzed patients around the time of transplant.
August 1982, AANNT journal,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients.
August 2010, Archives of medical science : AMS,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Vitamin K status in peritoneally dialyzed patients with chronic kidney disease.
January 2011, Acta biochimica Polonica,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Thyroid function and morphology in kidney transplant recipients, hemodialyzed, and peritoneally dialyzed patients.
December 2003, Transplantation proceedings,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Relationship between oxidative stress and extrinsic coagulation pathway in haemodialyzed patients.
March 2003, Thrombosis research,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Iron status and anemia control are related to peritoneal membrane properties in peritoneally dialyzed patients.
January 2023, Frontiers in medicine,
Jolanta Małyszko, and Jacek S Małyszko, and Tomasz Hryszko, and Krystyna Pawlak, and Michał Myśliwiec
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
February 2010, Thrombosis research,
Copied contents to your clipboard!