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Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships. 2002
Hing L Sham, and
Chen Zhao, and
Leping Li, and
David A Betebenner, and
Ayda Saldivar, and
Sudthida Vasavanonda, and
Dale J Kempf, and
Jacob J Plattner, and
Daniel W Norbeck
Pharmaceutical Discovery, R47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com
The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1' positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.
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Daniel W Norbeck
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Leping Li, and
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