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Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors. 2002
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. yuguang.wang@spcorp.com
We have discovered potent and selective xanthine PDE5 inhibitors. Compound 25 (PDE5 IC(50)=0.6 nM, PDE6/PDE5=101) demonstrated similar functional efficacy and PK profile to Sildenafil (PDE5 IC(50)=3.5 nM, PDE6/PDE5=7).
Related Publications
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
October 2012,
Journal of medicinal chemistry,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
June 2013,
Bioorganic & medicinal chemistry letters,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
January 2018,
Medicinal chemistry (Shariqah (United Arab Emirates)),
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
March 2018,
ChemMedChem,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
August 2009,
Bioorganic & medicinal chemistry letters,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
August 2019,
Bioorganic chemistry,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
March 2014,
European journal of medicinal chemistry,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
January 2002,
Journal of medicinal chemistry,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
September 2001,
Bioorganic & medicinal chemistry letters,
Yuguang Wang, and
Samuel Chackalamannil, and
Zhiyong Hu, and
Craig D Boyle, and
Claire M Lankin, and
Yan Xia, and
Ruo Xu, and
Theodros Asberom, and
Dmitri Pissarnitski, and
Andrew W Stamford, and
William J Greenlee, and
Jeffrey Skell, and
Stanley Kurowski, and
Subbarao Vemulapalli, and
Jairam Palamanda, and
Madhu Chintala, and
Ping Wu, and
Joyce Myers, and
Peng Wang
April 2009,
Bioorganic & medicinal chemistry letters,
