Fournier's gangrene after unrelated cord blood stem cell transplantation. 2002

C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
Department of Internal Medicine II, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

A 16-year-old boy with refractory acute myelogenous leukemia developed Fournier's gangrene as an early complication after two-antigen HLA-mismatched unrelated cord blood stem cell transplantation. On day 25 after the transplantation, he noted abrupt onset of penile swelling with miction pain. The penile inflammation rapidly extended posteriorly to involve the scrotum and perianal tissues, inferiorly to involve the thighs, and superiorly up the lower abdominal region within the next 36 h, and he died from sepsis on day 27. Fournier's gangrene presenting as a genitoperineal necrotizing fasciitis should be considered as a potential complication in umbilical-cord blood recipients in the cytopenic post-transplant phase.

UI MeSH Term Description Entries
D008297 Male Males
D006648 Histocompatibility The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts. HLA Incompatibility,Histoincompatibility,Human Leukocyte Antigen Incompatibility,Immunocompatibility,Tissue Compatibility,Compatibility, Tissue,HLA Incompatibilities,Histocompatibilities,Histoincompatibilities,Immunocompatibilities,Incompatibility, HLA,Tissue Compatibilities
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D015470 Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. Leukemia, Myelogenous, Acute,Leukemia, Nonlymphocytic, Acute,Myeloid Leukemia, Acute,Nonlymphocytic Leukemia, Acute,ANLL,Acute Myelogenous Leukemia,Acute Myeloid Leukemia,Acute Myeloid Leukemia with Maturation,Acute Myeloid Leukemia without Maturation,Leukemia, Acute Myelogenous,Leukemia, Acute Myeloid,Leukemia, Myeloblastic, Acute,Leukemia, Myelocytic, Acute,Leukemia, Myeloid, Acute, M1,Leukemia, Myeloid, Acute, M2,Leukemia, Nonlymphoblastic, Acute,Myeloblastic Leukemia, Acute,Myelocytic Leukemia, Acute,Myelogenous Leukemia, Acute,Myeloid Leukemia, Acute, M1,Myeloid Leukemia, Acute, M2,Nonlymphoblastic Leukemia, Acute,Acute Myeloblastic Leukemia,Acute Myeloblastic Leukemias,Acute Myelocytic Leukemia,Acute Myelocytic Leukemias,Acute Myelogenous Leukemias,Acute Myeloid Leukemias,Acute Nonlymphoblastic Leukemia,Acute Nonlymphoblastic Leukemias,Acute Nonlymphocytic Leukemia,Acute Nonlymphocytic Leukemias,Leukemia, Acute Myeloblastic,Leukemia, Acute Myelocytic,Leukemia, Acute Nonlymphoblastic,Leukemia, Acute Nonlymphocytic,Leukemias, Acute Myeloblastic,Leukemias, Acute Myelocytic,Leukemias, Acute Myelogenous,Leukemias, Acute Myeloid,Leukemias, Acute Nonlymphoblastic,Leukemias, Acute Nonlymphocytic,Myeloblastic Leukemias, Acute,Myelocytic Leukemias, Acute,Myelogenous Leukemias, Acute,Myeloid Leukemias, Acute,Nonlymphoblastic Leukemias, Acute,Nonlymphocytic Leukemias, Acute
D017809 Fatal Outcome Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept. Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal
D018805 Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. Bloodstream Infection,Pyaemia,Pyemia,Pyohemia,Blood Poisoning,Poisoning, Blood,Septicemia,Severe Sepsis,Blood Poisonings,Bloodstream Infections,Infection, Bloodstream,Poisonings, Blood,Pyaemias,Pyemias,Pyohemias,Sepsis, Severe,Septicemias
D018934 Fournier Gangrene An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. Fournier Disease,Fournier's Gangrene,Fournier's Disease,Fourniers Disease,Fourniers Gangrene,Gangrene, Fournier,Gangrene, Fournier's
D019115 Fasciitis, Necrotizing A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common. Fascitis, Necrotizing,Fasciitides, Necrotizing,Fascitides, Necrotizing,Necrotizing Fasciitides,Necrotizing Fasciitis,Necrotizing Fascitides,Necrotizing Fascitis

Related Publications

C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
April 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
June 2003, Pediatrics international : official journal of the Japan Pediatric Society,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
February 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
June 2017, Bone marrow transplantation,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
April 2006, Leukemia & lymphoma,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
June 2001, Reviews in clinical and experimental hematology,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
August 1998, International journal of hematology,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
June 2010, Clinical immunology (Orlando, Fla.),
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
February 2007, The British journal of dermatology,
C Yoshida, and K Kojima, and K Shinagawa, and D Hashimoto, and S Asakura, and S Takata, and M Tanimoto
April 2003, Pediatric nephrology (Berlin, Germany),
Copied contents to your clipboard!