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Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines. 2002
Yuzuru Higuchi, and
Jun-Ichi Asaumi, and
Jun Murakami, and
Toru Wakasa, and
Tetsuyoshi Inoue, and
Masahiro Kuroda, and
Koichi Shibuya, and
Hiroshi Shigehara, and
Shoji Kawasaki, and
Kazuhiro Fukui, and
Kanji Kishi, and
Yoshio Hiraki
Department of Oral and Maxillofacial Radiology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.
We reconstructed the recombinant p53-expressing adenovirus and examined its infections and effects in head and neck squamous cell carcinoma cell lines. Eight human head and neck squamous cell carcinoma cell lines were infected by the recombinant adenovirus harboring the lacZ gene (AxCAiLacZ) or the wild-type p53 gene (AxCAip53), and the effects were investigated. The eight cell lines were successfully infected by AxCAiLacZ at a level of more than 50%. The survival of all 8 squamous cell lines were inhibited in the range from 8 to 26.7% by only one treatment of the AxCAip53 infection. This result suggested that p53 gene therapy might become a useful tool in head and neck squamous cell carcinoma treatment.
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