Biomaterial Database

Wegener's granulomatosis is not a granulomatous disease. 2002

Dennis K Heffner

Department of Endocrine and Otorhinolaryngic-Head & Neck Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

The histologic diagnosis of Wegener's granulomatosis is usually challenging. It is made more so by the failure of most pathologists to realize that the disease is fundamentally neither a vasculitis nor a granulomatous reaction. This problem can contribute to delays in diagnosis and consequent adverse effects for patient prognosis. This article attempts to better describe the essence of Wegener's granulomatosis with the aim of enhancing diagnosis earlier in the course of the disease.

UI	MeSH Term	Description	Entries
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D006099	Granuloma	A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.	Granulomas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014657	Vasculitis	Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.	Angiitis,Angiitides,Vasculitides
D014890	Granulomatosis with Polyangiitis	A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.	Granulomatosis, Wegener's,Wegener Granulomatosis,Wegener's Granulomatosis,Granulomatosis with Polyangiitides,Granulomatosis, Wegener,Polyangiitides, Granulomatosis with,Polyangiitis, Granulomatosis with,with Polyangiitides, Granulomatosis,with Polyangiitis, Granulomatosis
D017441	Necrobiotic Disorders	A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis.	Necrobiosis,Disorder, Necrobiotic,Disorders, Necrobiotic,Necrobioses,Necrobiotic Disorder