BIOMAT Database Logo BIOMAT Database Logo

The mononuclear phagocyte system revisited. 2002

David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
Institute for Molecular Bioscience, University of Queensland, Australia. D.Hume@imb.uq.edu.au

The mononuclear phagocyte system (MPS) was defined as a family of cells comprising bone marrow progenitors, blood monocytes, and tissue macrophages. In this review, we briefly consider markers for cells of this lineage in the mouse, especially the F4/80 surface antigen and the receptor for macrophage colony-stimulating factor. The concept of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, the blurring of the boundaries between macrophages and other cells types arising from phenotypic plasticity and transdifferentiation, and evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. Nevertheless, there is a unity to cells of the MPS suggested by their location, morphology, and shared markers. We discuss the origins of macrophage heterogeneity and argue that macrophages and antigen-representing dendritic cells are closely related and part of the MPS.

UI MeSH Term Description Entries
D007963 Leukocytes, Mononuclear Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D010586 Phagocytes Cells that can carry out the process of PHAGOCYTOSIS. Phagocyte,Phagocytic Cell,Phagocytic Cells,Cell, Phagocytic,Cells, Phagocytic
D003713 Dendritic Cells Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION). Dendritic Cells, Interdigitating,Interdigitating Cells,Plasmacytoid Dendritic Cells,Veiled Cells,Dendritic Cells, Interstitial,Dendritic Cells, Plasmacytoid,Interdigitating Dendritic Cells,Interstitial Dendritic Cells,Cell, Dendritic,Cell, Interdigitating,Cell, Interdigitating Dendritic,Cell, Interstitial Dendritic,Cell, Plasmacytoid Dendritic,Cell, Veiled,Cells, Dendritic,Cells, Interdigitating,Cells, Interdigitating Dendritic,Cells, Interstitial Dendritic,Cells, Plasmacytoid Dendritic,Cells, Veiled,Dendritic Cell,Dendritic Cell, Interdigitating,Dendritic Cell, Interstitial,Dendritic Cell, Plasmacytoid,Interdigitating Cell,Interdigitating Dendritic Cell,Interstitial Dendritic Cell,Plasmacytoid Dendritic Cell,Veiled Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015870 Gene Expression The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. Expression, Gene,Expressions, Gene,Gene Expressions
D016186 Receptor, Macrophage Colony-Stimulating Factor A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation. Antigens, CD115,CD115 Antigens,CSF-1 Receptor,M-CSF Receptor,Macrophage Colony-Stimulating Factor Receptor,Proto-Oncogene Protein fms,Receptor, CSF-1,c-fms Protein,fms Proto-Oncogene Protein,CD115 Antigen,M-CSF Receptors,Macrophage Colony-Stimulating Factor Receptors,Receptors, CSF-1,Receptors, M-CSF,Receptors, Macrophage Colony-Stimulating Factor,Antigen, CD115,CSF-1 Receptors,M CSF Receptor,Macrophage Colony Stimulating Factor Receptor,Macrophage Colony Stimulating Factor Receptors,Proto-Oncogene Protein, fms,Receptor, CSF 1,Receptor, M-CSF,Receptor, Macrophage Colony Stimulating Factor,Receptors, CSF 1,Receptors, M CSF,Receptors, Macrophage Colony Stimulating Factor,c fms Protein,fms Proto Oncogene Protein

Related Publications

David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The mononuclear phagocyte system.
February 2006, Current opinion in immunology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The mononuclear phagocyte system.
January 1980, Verhandlungen der Deutschen Gesellschaft fur Pathologie,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
[The mononuclear phagocyte system].
June 1976, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The mononuclear phagocyte system and hemopoiesis.
January 1979, Advances in experimental medicine and biology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
Homeostasis in the mononuclear phagocyte system.
August 2014, Trends in immunology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The mononuclear phagocyte system in granulomas.
July 1985, The British journal of dermatology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
[Dysfunction of mononuclear phagocyte system].
March 1989, Nihon rinsho. Japanese journal of clinical medicine,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
Human mononuclear phagocyte system reunited.
May 2015, Seminars in cell & developmental biology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The RES and the mononuclear phagocyte system.
January 1976, Advances in experimental medicine and biology,
David A Hume, and Ian L Ross, and S Roy Himes, and R Tedjo Sasmono, and Christine A Wells, and Timothy Ravasi
The Mononuclear Phagocyte System of the Rat.
May 2021, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!