Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats. 2002

Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, Uppsala, Sweden. karolina.ploj@farmbio.uu.se

Melanocortin (MC) peptides are suggested to play a role in opiate dependence, where they antagonise the addictive properties of opiates. To further study the involvement of the MCs in drug dependence, we analysed the effects of the MC(4)-receptor antagonist HS014 (1 nmol/rat), and the non-selective MC-receptor agonist MTII (1 nmol/rat), using i.c.v. administration, on ethanol intake in alcohol-preferring AA rats. The rats had access to ethanol during 40 days, resulting in a mean ethanol intake of 6.6 g/kg/day, before treatment. One group received only artificial cerebrospinal fluid solution. MTII caused a reduction in ethanol intake and ethanol preference, whereas HS014 was without effect. No effect on water intake was observed. A decrease in food intake was detected after MTII, whereas HS014 induced an increase in food intake. Analysis of dynorphin B and Met-enkephalin-Arg(6)Phe(7) immunoreactive levels revealed that MTII and HS014 altered opioid peptide levels in several brain areas and the pituitary gland of the rats with an established ethanol intake. This is the first report showing that manipulation of the MC-receptor system changes ethanol intake in chronically ethanol-drinking AA rats. In addition, manipulation of the MC system modulates ethanol-induced changes in opioid peptide levels.

UI MeSH Term Description Entries
D008024 Ligands A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed) Ligand
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D010456 Peptides, Cyclic Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL). Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005260 Female Females
D000428 Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D000521 alpha-MSH A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. MSH, alpha,alpha Intermedin,alpha-Melanocyte-Stimulating Hormone,(Des-Acetyl)-alpha-MSH,(Desacetyl)alpha-MSH,ACTH (1-13),ACTH (1-13)NH2,ACTH(1-13),Acetylated ACTH (1-13)NH2,Adrenocorticotropin (1-13)NH2,DE-alpha-MSH,Des-Acetyl MSH,Desacetyl alpha-MSH,Desacetyl alpha-Melanocyte-Stimulating Hormone,MSH, (Desacetyl)alpha-,alpha-Melanotropin,Desacetyl alpha MSH,Desacetyl alpha Melanocyte Stimulating Hormone,Hormone, Desacetyl alpha-Melanocyte-Stimulating,Hormone, alpha-Melanocyte-Stimulating,Intermedin, alpha,MSH, Des-Acetyl,alpha MSH,alpha Melanocyte Stimulating Hormone,alpha Melanotropin,alpha-MSH, Desacetyl,alpha-Melanocyte-Stimulating Hormone, Desacetyl
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D044101 Receptors, Melanocortin A family of G-protein-coupled receptors that have specificity for MELANOCYTE-STIMULATING HORMONES and ADRENOCORTICOTROPIC HORMONE. There are several subtypes of melanocortin receptors, each having a distinct ligand specificity profile and tissue localization. Melanocortin Receptors,Melanocortin Receptor,Receptor, Melanocortin
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
May 2018, Psychopharmacology,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
January 2006, Peptides,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
September 1994, European journal of pharmacology,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
October 2016, Alcoholism, clinical and experimental research,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
November 2014, Psychopharmacology,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
June 2003, Addiction biology,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
May 2013, Brain sciences,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
September 2014, Brain research,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
January 2003, Alcoholism, clinical and experimental research,
Karolina Ploj, and Erika Roman, and Ants Kask, and Petri Hyytiä, and Helgi B Schiöth, and Jarl E S Wikberg, and Ingrid Nylander
May 2002, Pharmacology, biochemistry, and behavior,
Copied contents to your clipboard!