BIOMAT Database Logo BIOMAT Database Logo

Synthesis of new sulfonamide inhibitors of carbonic anhydrase. 2002

O Arslan, and U Cakir, and H I Ugraş
Balikesir University Faculty of Science and Art, Department of Chemistry, Balikesir, 10100, Turkey. oktay@balikesir.edu.tr

Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D002257 Carbonic Anhydrase Inhibitors A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. Carbonate Dehydratase Inhibitor,Carbonate Dehydratase Inhibitors,Carbonic Anhydrase Inhibitor,Carboxyanhydrase Inhibitor,Carboxyanhydrase Inhibitors,Anhydrase Inhibitor, Carbonic,Dehydratase Inhibitor, Carbonate,Inhibitor, Carbonate Dehydratase,Inhibitor, Carbonic Anhydrase,Inhibitor, Carboxyanhydrase,Inhibitors, Carbonate Dehydratase,Inhibitors, Carbonic Anhydrase,Inhibitors, Carboxyanhydrase
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001667 Binding, Competitive The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements. Competitive Binding
D013449 Sulfonamides A group of compounds that contain the structure SO2NH2. Sulfonamide,Sulfonamide Mixture,Sulfonamide Mixtures,Mixture, Sulfonamide,Mixtures, Sulfonamide
D020128 Inhibitory Concentration 50 The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture. IC50,Concentration 50, Inhibitory
D024401 Carbonic Anhydrase I A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial cells, and the gastrointestinal mucosa. EC 4.2.1.- CA I Hiroshima-1,Carbonic Anhydrase B,Carbonic Anhydrase I Hiroshima-1,Carbonic Anhydrase Isoenzyme B,Anhydrase B, Carbonic,CA I Hiroshima 1,Carbonic Anhydrase I Hiroshima 1
D024402 Carbonic Anhydrase II A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.- Carbonic Anhydrase C,Carbonic Anhydrase Isoenzyme C

Related Publications

O Arslan, and U Cakir, and H I Ugraş
Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors.
August 2012, Journal of enzyme inhibition and medicinal chemistry,
O Arslan, and U Cakir, and H I Ugraş
Pharmacological Properties of Sulfonamide Derivatives, New Inhibitors of Carbonic Anhydrase.
June 2023, Bulletin of experimental biology and medicine,
O Arslan, and U Cakir, and H I Ugraş
[Sulfonamide inhibitors of tubular function, carbonic anhydrase inhibitors & hypoglycemics].
January 1957, Actualites pharmacologiques,
O Arslan, and U Cakir, and H I Ugraş
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.
December 2017, ACS medicinal chemistry letters,
O Arslan, and U Cakir, and H I Ugraş
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
July 2007, Bioorganic & medicinal chemistry letters,
O Arslan, and U Cakir, and H I Ugraş
[Effects of carbonic anhydrase inhibitors on sulfonamide excretion].
December 1959, Wiener klinische Wochenschrift,
O Arslan, and U Cakir, and H I Ugraş
[Sulfonamide inhibitors of carbonic anhydrase in pediatric therapy].
January 1957, La Pediatria,
O Arslan, and U Cakir, and H I Ugraş
Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
July 2008, Organic & biomolecular chemistry,
O Arslan, and U Cakir, and H I Ugraş
Synthesis and evaluation of new carbonic anhydrase inhibitors.
May 2011, Bioorganic & medicinal chemistry,
O Arslan, and U Cakir, and H I Ugraş
Synthesis and characterization of metal complexes of heterocyclic sulfonamide as carbonic anhydrase inhibitors.
April 2013, Journal of enzyme inhibition and medicinal chemistry,
Copied contents to your clipboard!