The author presents an analysis of the results of the combination chemotherapy with natulan, vincristin, novembichine and prednisolone in 43 patients showing generalized lymphogranulomatosis, mainly with recurrences following radiation and chemotherapy with different antitumor substances. The results of the combination chemotherapy were compared with the data obtained in management of 94 patients having lymphogranulomatosis, stage III-IV, with natulan solely. It is shown that the combination therapy is effective, in principle, and provides an opportunity to gain objective remission in 65% of cases. A therapeutic effect of polychemotherapy depends on the administered total doses of the substances. A regimen consisting of no less than 5-6 cycles seems to be an optimum one, since it yields the greatest incidence and duration of remissions. As compared with the results of polychemotherapy in the fiven contigency of patients, natulan, used as a single tool of the specific therapy, shows a somewhat better effect.