-transparent.png){kind=logo}
Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-alpha production. 2002
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
Fukui Research Institute, Ono Pharmaceutical Co., Ltd., Yamagishi, Mikuni, Sakai, Fukui, Japan. to.matsui@ono.co.jp
2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-alpha production. Structural optimization was started with the chemical modification of 6. The discovery of another chemical leads 7, 8, 10 and 16 for the development of structurally new inhibitors of TNF-alpha production is reported.
Related Publications
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
March 2002,
Bioorganic & medicinal chemistry letters,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
December 2002,
Bioorganic & medicinal chemistry,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
November 2003,
Bioorganic & medicinal chemistry letters,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
September 2015,
Acta pharmaceutica (Zagreb, Croatia),
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
May 2004,
Bioorganic & medicinal chemistry letters,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
July 2023,
Journal of agricultural and food chemistry,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
July 2019,
Chemistry & biodiversity,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
January 1996,
Advances in experimental medicine and biology,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
December 2022,
European journal of medicinal chemistry,
Toshiaki Matsui, and
Shinya Takahashi, and
Naoki Matsunaga, and
Kazunori Nakamura, and
Nagashige Omawari, and
Masaru Sakai, and
Wataru Kamoshima, and
Kouichiro Terai, and
Hiroyuki Ohno, and
Takaaki Obata, and
Hisao Nakai, and
Masaaki Toda
November 2023,
Molecules (Basel, Switzerland),
