BIOMAT Database Logo BIOMAT Database Logo

Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells. 2003

Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA.

It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1 alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4 alpha.

UI MeSH Term Description Entries
D010750 Phosphoproteins Phosphoprotein
D011233 Precipitin Tests Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate. Precipitin Test,Test, Precipitin,Tests, Precipitin
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D005952 Glucose-6-Phosphatase An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9. Glucosephosphatase,Glucose 6-Phosphatase,Glucose-6-Phosphate Phosphohydrolase,Glucose 6 Phosphatase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining
D014157 Transcription Factors Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. Transcription Factor,Factor, Transcription,Factors, Transcription

Related Publications

Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Characterization of the transactivation domain in the peroxisome-proliferator-activated receptor gamma co-activator (PGC-1).
May 2007, The Biochemical journal,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription.
June 2001, The Journal of biological chemistry,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).
September 2013, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
PP053. The role of peroxisome proliferator-activated receptor gamma co-activator 1-alpha in pregnancy.
April 2013, Pregnancy hypertension,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
[Effect of nuclear factor-kappaB on peroxisome proliferator activated receptor gamma expression in Ana-1 cells].
January 2009, Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Garlic-derived diallyl disulfide modulates peroxisome proliferator activated receptor gamma co-activator 1 alpha in neuroblastoma cells.
February 2013, Biochemical pharmacology,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response.
October 2008, The Biochemical journal,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha.
April 2003, The Biochemical journal,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
February 2003, Endocrine reviews,
Jared N Boustead, and Beth T Stadelmaier, and Angela M Eeds, and Peter O Wiebe, and Christina A Svitek, and James K Oeser, and Richard M O'Brien
Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy.
August 2019, Psychological medicine,
Copied contents to your clipboard!