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In this study, we determined curcumin's anticancer and chemopreventive effects in mice bearing Ehrlich ascites tumor by evaluation of cancer biomarkers, sialic acid level and sialidase activity. Both plasma sialic acid level and sialidase activity increased significantly in the mice group with Ehrlich ascites tumor. When the tumor groups fed with curcumin and fed with sesame oil were compared, sialic acid level and sialidase activity in ascites fluid significantly reduced in the group fed with curcumin in addition to the increases of plasma sialic acid level and sialidase activity. The tumor group fed with curcumin lived twice longer than the one fed with sesame oil. Curcumin as a phenolic compound decreased all these parameters in Ehrlich ascites tumors and lengthened survival by 88% in the mice with tumor. We concluded that curcumin has anticancer activity.
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
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Cellular and molecular biology,
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
January 2014,
Journal of cancer research and therapeutics,
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
January 2011,
Iranian journal of pharmaceutical research : IJPR,
Naile Ozen, and
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Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
January 1968,
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Naile Ozen, and
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Emine Kokoglu
January 1972,
Osaka city medical journal,
Naile Ozen, and
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January 1983,
Neoplasma,
Naile Ozen, and
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Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
January 1976,
Cancer research,
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
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Bulletin du cancer,
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
November 2011,
Basic & clinical pharmacology & toxicology,
Naile Ozen, and
Ezel Uslu, and
Metehan Ozen, and
Seval Aydin, and
Tuncay Altug, and
Ahmet Belce, and
Emine Kokoglu
January 1978,
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