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Urinary excretion of metabolites of the kynurenine pathway before and after a loading dose of 2 g L-tryptophan was studied in 31 bladder cancer patients from the Copenhagen area. Only 2 patients (6 per cent) showed abnormal tryptophan metabolism, and both patients excreted increased amounts of only 3-hydroxykynurenine after a loading dose of 2 g L-tryptophan. The percentage of bladder cancer patients with abnormal tryptophan metabolism is compared with the percentage found in other parts of the world. It is suggested that these findings may indicate that tryptophan metabolites do not play a major role in the genesis of bladder cancer among bladder cancer patients from the Copenhagen area. Other etiologic factors should be looked for.
H Wolf, and
R R Brown, and
K Nyholm
May 1968,
Investigative urology,
H Wolf, and
R R Brown, and
K Nyholm
November 1989,
Zeitschrift fur Urologie und Nephrologie,
H Wolf, and
R R Brown, and
K Nyholm
January 1960,
Acta - Unio Internationalis Contra Cancrum,
H Wolf, and
R R Brown, and
K Nyholm
July 1969,
Journal of the National Cancer Institute,
H Wolf, and
R R Brown, and
K Nyholm
April 1972,
American Industrial Hygiene Association journal,
H Wolf, and
R R Brown, and
K Nyholm
May 1973,
Cancer research,
H Wolf, and
R R Brown, and
K Nyholm
April 1976,
The Journal of urology,
H Wolf, and
R R Brown, and
K Nyholm
November 1956,
The Biochemical journal,
H Wolf, and
R R Brown, and
K Nyholm
January 1975,
Zeitschrift fur klinische Chemie und klinische Biochemie,
H Wolf, and
R R Brown, and
K Nyholm
July 1974,
Cancer research,
