Biomaterial Database

Positional information: knowing where you are in a limb. 2002

Malcolm Maden

MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, Guy's Campus, London Bridge, SE1 1UL, London, UK. malcolm.maden@kcl.ac.uk

In the regenerating amphibian limb, positional information has traditionally been considered in terms of short-range cell-cell interactions, not long-range diffusion gradients. A molecule discovered in a differential screen of regenerating limbs turns out to be precisely such a cell surface component, the newt ortholog of mouse CD59.

UI	MeSH Term	Description	Entries
D011187	Posture	The position or physical attitude of the body.	Postures
D011434	Proprioception	Sensory functions that transduce stimuli received by proprioceptive receptors in joints, tendons, muscles, and the INNER EAR into neural impulses to be transmitted to the CENTRAL NERVOUS SYSTEM. Proprioception provides sense of stationary positions and movements of one's body parts, and is important in maintaining KINESTHESIA and POSTURAL BALANCE.	Labyrinthine Sense,Position Sense,Posture Sense,Sense of Equilibrium,Vestibular Sense,Sense of Position,Equilibrium Sense,Sense, Labyrinthine,Sense, Position,Sense, Posture,Sense, Vestibular
D012038	Regeneration	The physiological renewal, repair, or replacement of tissue.	Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D002450	Cell Communication	Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.	Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D005121	Extremities	The farthest or outermost projections of the body, such as the HAND and FOOT.	Limbs,Extremity,Limb
D000663	Amphibians	VERTEBRATES belonging to the class amphibia such as frogs, toads, newts and salamanders that live in a semiaquatic environment.	Amphibia,Amphibian
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012455	Salamandridae	A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.	Newts,Taricha,Newt,Tarichas
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018957	CD59 Antigens	Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)	Antigens, CD59,HRF20,Homologous Restriction Factor 20,MACIF,Membrane Attack Complex Inhibition Factor,Protectin,CD59 Antigen,Membrane Inhibitor of Reactive Lysis