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The coefficient of true intestinal calcium absorption (a value) was measured by a double radioisotope technique in 29 chronic renal failure patients (serum creatinine levles 2.5-19.5 mg%) aged 20-75 years. The mean log 10 a (+/- standard error) of these subjects (1.197 +/- 0.031) was significantly lower (p less than 0.001) than that of 52 controls (1.532 +/- 0.024), the geometric mean of the renal failure group (15.7%) being approximately half (46%) of that of the controls (33.9%). The decrease of a value of the uremic patients was more pronounced in the younger than in the older subjects as shown by a statistically significant (r = 0.570; p less than 0.001) positive curvilinear, relationship between a value and age. The lowest intestinal calcium absorptions were observed in patients with a serum creatinine level of approximately 11 mg%, the a values increasing progressively with lower or larger than 11 mg% serum creatinine levels, as shown by a statistically significant (r = 0.485; p less than 0.01) parabolic relationship between a value and serum creatinine. The possible mechanism(s) of this relationship are discussed.
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
December 1968,
German medical monthly,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
April 1973,
Kidney international,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
April 1973,
Kidney international,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
June 1979,
FEBS letters,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
May 1979,
The American journal of physiology,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
January 2002,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
January 1981,
Nephron,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
January 1981,
Acta physiologica latino americana,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
July 1951,
Annals of internal medicine,
T H Mountokalakis, and
P N Singhellakis, and
C C Alevizaki, and
K Virvidakis, and
D G Ikkos
August 1973,
Kidney international,
