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Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. 2002
Asim K Duttaroy, and
Jonathon Taylor, and
Margaret J Gordon, and
Nigel Hoggard, and
Fiona M Campbell
Institute for Nutrition Research, University of Oslo, P.O. Box 1046, Blindern, N-0316, Oslo, Norway. a.k.d@basalmed.uio.no
Arachidonic acid at 100 nM stimulated internalisation of 125I-leptin in human placental choriocarcinoma (BeWo) cells by 3-fold compared with controls. In contrast, eicosapentaenoic acid at similar concentration decreased internalisation of leptin by 2-fold. Use of ibuprofen and indomethacin (inhibitors of prostaglandin synthesis) inhibited the stimulatory effect of arachidonic acid. Prostaglandin E(2), a cyclooxygenase metabolite of arachidonic acid, stimulated internalisation of leptin by these cells. All these data demonstrate that stimulation of leptin internalisation by arachidonic acid in placental trophoblasts may be mediated via prostaglandin E(2).
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