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The efficacy of plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) as markers of the presence and activity of vasculiditic processes in rheumatic diseases were evaluated, first by serial measurement of their levels in a patient with rheumatoid arthritis and a chronic leg ulcer in the course of treatment, and second in 11 patients with rheumatoid arthritis without cutaneous vasculitis, and in nine patients with a variety of rheumatic diseases with cutaneous vasculitis. In the former, plasma levels of beta-TG and PF4 were elevated and slowly reduced in parallel with healing, raised again after relapse, and normalized after disappearance of the leg ulcer. In the latter, both plasma levels were elevated in all of the nine patients with cutaneous vascular lesions and in one of the 11 patients rheumatoid arthritis without skin lesions. Levels of beta-TG and PF4 may be useful to estimate the presence of vascular lesions in rheumatic disorders.
T Yamamoto, and
T Chikugo, and
Y Tanaka
August 1997,
Biological psychiatry,
T Yamamoto, and
T Chikugo, and
Y Tanaka
December 2008,
Allergology international : official journal of the Japanese Society of Allergology,
T Yamamoto, and
T Chikugo, and
Y Tanaka
July 1983,
Deutsche medizinische Wochenschrift (1946),
T Yamamoto, and
T Chikugo, and
Y Tanaka
February 1988,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
T Yamamoto, and
T Chikugo, and
Y Tanaka
July 1986,
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T Yamamoto, and
T Chikugo, and
Y Tanaka
January 1982,
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T Yamamoto, and
T Chikugo, and
Y Tanaka
January 1980,
Thrombosis research,
T Yamamoto, and
T Chikugo, and
Y Tanaka
January 1981,
Thrombosis research,
T Yamamoto, and
T Chikugo, and
Y Tanaka
December 1988,
Zhonghua xin xue guan bing za zhi,
T Yamamoto, and
T Chikugo, and
Y Tanaka
February 1981,
Blood,
