Optimization of electromagnetic phased-arrays for hyperthermia via magnetic resonance temperature estimation. 2002

Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801-2991, USA. m.e.kowalski@ieee.org

A technique for the optimization of electromagnetic annular phased arrays (APAs) for therapeutic hyperthermia has been developed and implemented. The controllable inputs are the amplitudes and phases of the driving signals of each element of the array. Magnetic resonance imaging (MRI) is used to estimate noninvasively the temperature distribution based on the temperature dependence of the proton resonance frequency (PRF). A parametric model of the dynamics that couple the control inputs to the resultant temperature elevations is developed based on physical considerations. The unknown parameters of this model are estimated during a pretreatment identification phase and can be continuously updated as new measurement data become available. Based on the parametric model, a controller automatically chooses optimal phases and amplitudes of the driving signals of the APA. An advantage of this approach to optimizing the APA is that no a priori information is required, eliminating the need for patient-specific computational modeling and optimization. Additionally, this approach represents a first step toward employing temperature feedback to make the optimization of the APA robust with respect to modeling errors and physiological changes. The ability of the controller to choose therapeutically beneficial driving amplitudes and phases is demonstrated via simulation. Experimental results are presented which demonstrate the ability of the controller to choose optimal phases for the APA using only information from magnetic resonance thermometry (MRT).

UI MeSH Term Description Entries
D006979 Hyperthermia, Induced Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs. Fever Therapy,Hyperthermia, Local,Hyperthermia, Therapeutic,Thermotherapy,Induced Hyperthermia,Therapeutic Hyperthermia,Therapy, Fever,Local Hyperthermia
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008872 Microwaves That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies. EHF Waves,Extremely High Frequency Radio Waves,Micro Wave,Micro Waves,Ultrahigh Frequency Waves,Microwave Radiation,EHF Wave,Micro Waves,Microwave,Microwave Radiations,Radiation, Microwave,Ultrahigh Frequency Wave,Wave, EHF,Wave, Micro,Wave, Ultrahigh Frequency,Waves, Micro
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010591 Phantom Limb Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30) Pseudomelia,Phantom Limb Pain,Phantom Pain,Phantom Sensation,Limb Pain, Phantom,Limb Pains, Phantom,Limb, Phantom,Limbs, Phantom,Pain, Phantom,Pain, Phantom Limb,Pains, Phantom,Pains, Phantom Limb,Phantom Limb Pains,Phantom Limbs,Phantom Pains,Phantom Sensations,Pseudomelias,Sensation, Phantom,Sensations, Phantom
D011786 Quality Control A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed) Control, Quality,Controls, Quality,Quality Controls
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D004574 Electromagnetic Fields Fields representing the joint interplay of electric and magnetic forces. Electromagnetic Field,Field, Electromagnetic,Fields, Electromagnetic
D005246 Feedback A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system. Feedbacks

Related Publications

Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
January 2001, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
December 2014, Medicine,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
January 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
December 2016, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
March 2003, Physics in medicine and biology,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
January 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
January 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
January 1992, IEEE transactions on ultrasonics, ferroelectrics, and frequency control,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
November 2003, IEEE transactions on bio-medical engineering,
Marc E Kowalski, and Babak Behnia, and Andrew G Webb, and Jian-Ming Jin
December 2021, IEEE transactions on biomedical circuits and systems,
Copied contents to your clipboard!