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Undernutrition and tetracycline half life. 1976

R A Shastri, and K Krishnaswamy

The plasma half life of tetracycline hydrochloride was determined in groups of well-nourished and undernourished subjects employing two dosage schedules and two routes of administration, namely oral and parenteral. Protein binding of the drug was estimated and relative volume distribution was calculated. The results indicated that in undernourished subjects, the half life of tetracycline hydrochloride, protein binding and relative volume distribution were all significantly low as compared to well-nourished subjects. The elimination rate was considerably higher in the undernourished groups, which accounted for the shorter half life. These data suggest that to maintain adequate serum concentrations of the drug in undernourished subjects, tetracycline needs to be given at more frequent intervals.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009748 Nutrition Disorders Disorders caused by nutritional imbalance, either overnutrition or undernutrition. Nutritional Disorders,Nutrition Disorder,Nutritional Disorder
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D012709 Serum Albumin A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules. Plasma Albumin,Albumin, Serum
D013752 Tetracycline A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. 4-Epitetracycline,Achromycin,Achromycin V,Hostacyclin,Sustamycin,Tetrabid,Tetracycline Hydrochloride,Tetracycline Monohydrochloride,Topicycline,4 Epitetracycline

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