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A 300-mug oral dose of clonidine was administered to 5 normal volunteers and measurements of plasma concentration and effects upon blood pressure, heart rate, circulatory reflexes, sedation, and dry mouth were made for the following 8 hr. The plasma concentration rose to a peak of 1.02 +/- 0.52 ng/ml (SD) at 90 min and fell with a mean half-life of 12.7 hr. Blood pressure of the group fell from 111.0/77.0 to 87.2/60.4 after 3 hr and was 95.2/62.2 mm Hg at 8 hr. Heart rate in recumbency was slowed. Marked sedation and a fall in salivary flow followed the same time-course as the plasma concentration. The cold pressor response was reduced but the Valsalva overshoot was little affected.
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
February 1983,
Chest,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
May 1988,
Clinical pharmacokinetics,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
April 1983,
Sheng li ke xue jin zhan [Progress in physiology],
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
May 1973,
Bollettino chimico farmaceutico,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
January 2006,
Veterinary therapeutics : research in applied veterinary medicine,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
January 1988,
La Ricerca in clinica e in laboratorio,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
July 1983,
American heart journal,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
September 1981,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
January 1994,
Epilepsia,
C T Dollery, and
D S Davies, and
G H Draffan, and
H J Dargie, and
C R Dean, and
J L Reid, and
R A Clare, and
S Murray
March 1994,
Clinical pharmacokinetics,
