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Circular dichroism spectra on angiotensin II and analogs, and its truncated N-terminal and C-terminal peptides were determined in fluroinated alcohols under several conditions in the peptide or aromatic spectral regions. The following conclusions were suggested: (a) evidence for a beta structure for angiotensin II; (b) evidence for a folding at the N-terminal and C-terminal part of the molecule; (c) an interaction involving the C-terminal residue which decreases progressively when phenylalanine is replaced by isoleucine and then by alanine; (d) the N-terminal amino acid seems to play an important role in the overall conformation of the molecule possibly by interacting with the C-terminus, its absence in the 2 -- 8 heptapeptide giving rise to a more pronounced signal than angiotensin II; (e) in trifluoroethanol the conformation of these peptides is well defined and fits well with observed structure-activity relationships and observed binding data. There is a loss of this relationship when these solvents are diluted with water.
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
November 1987,
Biophysical chemistry,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
January 1978,
Molekuliarnaia biologiia,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
April 1977,
Biochemical and biophysical research communications,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
December 1971,
European journal of biochemistry,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
May 1968,
Biochemistry,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
January 1975,
Bioinorganic chemistry,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
January 1981,
Methods in enzymology,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
January 1992,
Methods in enzymology,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
April 1967,
Biochemistry,
D Greff, and
S Fermandjian, and
P Fromageot, and
M C Khosla, and
R R Smeby, and
F M Bumpus
November 1970,
Biochimica et biophysica acta,
