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[Multicenter Study of Efficacy and Safety of a Preparation of Lovastatin in Patients With Ischemic Heart Disease and Mild or Moderate Hypercholesterolemia] 2001

Iu. P. Nikitin, and G. I. Simonova, and V. Iu. Mareev, and E. V. Shliakhto, and O. A. Berkovich, and F. T. Ageev
Cardiology Research Complex, 3rd Cherepkovskaia, 15a, 121552 Moscow, Russia.

Ninety patients with ischemic heart disease and mild or moderate hypercholesterolemia were included in a multicenter study of efficacy and safety of a preparation of lovastatin (Holetar, KRKA). After 6 weeks of a diet period 46 patients remained on diet and in 44 patients lovastatin was added to diet for 12 weeks. All patients received 20 mg/day for 6 weeks. If after 6 weeks on lovastatin target level of low density lipoprotein cholesterol (LDL CH, 3.0 mmol/l) was not achieved the dose was doubled. Target LDL CH level was achieved in 47% and 58% of patients by the end of 6 and 12 weeks, respectively. The 20 mg dose lowered levels of LDLCH by 27% and of triglycerides by 10%. The drug was well tolerated.

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