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The effects of low doses of deltamethrin administered to female rats on the reproductive system of male offspring were examined. The dams (n=10-12/group) were treated daily by oral gavage with 0, 1.0, 2.0, and 4.0 mg deltamethrin/kg from day 1 of pregnancy to day 21 of lactation. Maternal and reproductive outcome data and male sexual development landmarks were assessed. Fertility, sexual behavior, and a large number of reproductive endpoints, such as organ weights, sperm evaluations, testosterone concentration, and testicular histology were examined on adult male offsprings. No signs of maternal toxicity were detected at the dose levels tested. Significantly adverse effects were only seen on testicular and epididymal absolute weights and the diameter of seminiferous tubules in the group treated with the highest dose of deltamethrin (4.0 mg/kg). The results indicate that in utero and lactational exposure to deltamethrin may induce subtle changes in reproductive behavior and physiology of male offspring rats at dose levels that do not cause maternal toxicity.
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
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Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
March 2016,
Andrology,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
April 2024,
Ecotoxicology and environmental safety,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
March 1997,
Human & experimental toxicology,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
May 2023,
Reproduction, fertility, and development,
Anderson J M Andrade, and
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Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
June 2019,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
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Reproduction, nutrition, development,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
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Toxicology and applied pharmacology,
Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
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Anderson J M Andrade, and
Samanta Araújo, and
Gladys M Santana, and
Masahiko Ohi, and
Paulo R Dalsenter
November 2018,
Wei sheng yan jiu = Journal of hygiene research,
