Biomaterial Database

Absorption into silicone rubber membranes from powders and aqueous solutions. 2003

Kelly D McCarley, and Annette L Bunge

Chemical Engineering Department, Colorado School of Mines, Golden, CO 80401, USA.

This study compared the rate and amount of absorption from aqueous solutions and pure powders of 3- and 4-cyanophenol (CP) into silicone rubber (SR) membranes. SR membranes were cast directly onto a zinc-selenide attenuated total reflectance (ATR) crystal, which was then mounted on a Fourier transform infrared (FTIR) spectrometer. CP was presented to the SR membrane from aqueous solutions or powders sufficient to completely cover the membrane surface. The concentration of CP in the membrane at the interface with the crystal was determined by IR absorption of the C triple bond N stretch. The amount of CP in the SR membrane at steady state was determined by extraction and UV absorption measurements of the extract. The concentration of CP in SR membranes was found to depend weakly on the concentration of the aqueous solution. The amount of CP in SR membranes equilibrated with pure powders was essentially the same as for the CP-saturated solutions. Diffusion coefficients for 3 and 4-CP (2.8+/-0.2 and 2.5+/-0.6 x 10(-7) cm(2) s(-1), respectively) were not statistically different. The absorption rate of CP into SR membranes was almost the same from the powder and aqueous solution indicating that the rate of mass transfer from the powder to membrane was larger than 0.04 cm h(-1).

UI	MeSH Term	Description	Entries
D010636	Phenols	Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D011208	Powders	Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)	Powder
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D012826	Silicone Elastomers	Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.	Elastomers, Silicone,Rubber Silicone,Silicone Rubber,Elastosil,Microfil,SE-30,Elastosils,Microfils,SE 30,SE30,Silicone Elastomer
D012869	Skin Absorption	Uptake of substances through the SKIN.	Absorption, Skin,Intracutaneous Absorption,Intradermal Absorption,Percutaneous Absorption,Transcutaneous Absorption,Transdermal Absorption,Absorption, Intracutaneous,Absorption, Intradermal,Absorption, Percutaneous,Absorption, Transcutaneous,Absorption, Transdermal,Absorptions, Intracutaneous,Absorptions, Intradermal,Absorptions, Percutaneous,Absorptions, Skin,Absorptions, Transcutaneous,Absorptions, Transdermal,Intracutaneous Absorptions,Intradermal Absorptions,Percutaneous Absorptions,Skin Absorptions,Transcutaneous Absorptions,Transdermal Absorptions
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D012996	Solutions	The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)	Solution
D017550	Spectroscopy, Fourier Transform Infrared	A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.	FTIR,Fourier Transform Infrared Spectroscopy,Spectroscopy, Infrared, Fourier Transform