[Application of continuous epidural analgesia with ropivacaine and fentanyl during delivery]. 2002

Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
Department of Gynecology and Obstetrics, First Affiliated Hospital of the Medical College of Ji'nan University, Guangzhou 510632, China.

OBJECTIVE To evaluate the safety and efficiency of ropivacaine and fentanyl for continuous epidural analgesia during delivery. METHODS Altogether 98 full-term primigravidas with vertex presentation were selected for this study. Epidural catheter was placed during delivery with the cervical dilation of 3 cm, and the mixture of 0.2% ropivacaine and 2 microgram/ml fentanyl at the initial dose of 5 ml was given for continuous epidural analgesia. Drug infusion was discontinued when the second stage of delivery started. Another 98 primigravidas of similar conditions without analgesia served as the control group. RESULTS Analgesic group showed obvious pain-relieving effect (P<0.001) during the delivery, in which the active phase was significantly shortened (P<0.05). No obvious adverse effect arose in the mother and fetuses from the administration of analgesia. CONCLUSIONS Continuous epidural analgesia by pumping ropivacaine and fentanyl is effective and convenient for pain relief during delivery, and can be beneficial to the smooth progress of delivery.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005283 Fentanyl A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078) Phentanyl,Duragesic,Durogesic,Fentanest,Fentanyl Citrate,Fentora,R-4263,Sublimaze,Transmucosal Oral Fentanyl Citrate,R 4263,R4263
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077212 Ropivacaine An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons. 1-Propyl-2',6'-pipecoloxylidide,AL 381,AL-381,LEA 103,LEA-103,Naropeine,Naropin,Ropivacaine Hydrochloride,Ropivacaine Monohydrochloride,Ropivacaine Monohydrochloride, (S)-isomer,1 Propyl 2',6' pipecoloxylidide,AL381,LEA103
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000577 Amides Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amide
D000779 Anesthetics, Local Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. Anesthetics, Conduction-Blocking,Conduction-Blocking Anesthetics,Local Anesthetic,Anesthetics, Topical,Anesthetic, Local,Anesthetics, Conduction Blocking,Conduction Blocking Anesthetics,Local Anesthetics,Topical Anesthetics
D015360 Analgesia, Epidural The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation. Epidural Analgesia
D016362 Analgesia, Obstetrical The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS. Obstetrical Analgesia,Analgesia, Obstetric,Obstetric Analgesia

Related Publications

Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
September 2006, British journal of anaesthesia,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
February 2010, Middle East journal of anaesthesiology,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
May 2001, Anesthesia and analgesia,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
September 2006, Zhonghua wai ke za zhi [Chinese journal of surgery],
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
January 2006, Anesteziologiia i reanimatologiia,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
March 2000, Anesthesia and analgesia,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
January 2004, European journal of gynaecological oncology,
Xiao-Qing Luo, and Xue-Song Gao, and Xue-Mei Peng, and Jin-Rong Lin
October 2000, Revista espanola de anestesiologia y reanimacion,
Copied contents to your clipboard!