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Urinary kallikrein excretion was studied in a number of animal models of hypertension. Kallikrein excretion was subnormal in spontaneously hypertensive rats as compared to Wistar/Kyoto rats and in rats made hypertensive by a clip on one renal artery. Kallikrein excretion was supranormal in rats made hypertensive by desoxycorticosterone and salt and in rats receiving desoxycorticosterone alone. It was subnormal after bilateral adrenalectomy. Kallikrein excretion increased in normotensive rats fed a low-sodium diet but was unchanged by a high-sodium diet. Thus, kallikrein excretion responded to changes in activity of sodium-retaining steroids and was not correlated with excretion of salt or water. In studies in dogs with stenosis of one renal artery kallikrein excretion was decreased on the stenoic side and the decrease correlated highly with the reduction in renal blood flow. While the role of the kallikrein-kinin system is still unclear the data indicate that the kidney may modify the initiation or maintenance of hypertension via this potent vasodilator system.
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
January 1986,
Advances in experimental medicine and biology,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
January 1976,
Perspectives in nephrology and hypertension,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
September 1976,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
June 1986,
Archives des maladies du coeur et des vaisseaux,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
January 1980,
Lancet (London, England),
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
January 1988,
The Journal of diabetic complications,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
February 1980,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
November 1973,
Experientia,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
August 1975,
Acta pharmacologica et toxicologica,
H R Keiser, and
R G Geller, and
H S Margolius, and
J J Pisano
August 1975,
The Tohoku journal of experimental medicine,
