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Free and protein-bound serum sugars and serum lipids were analyzed in 65 adult diabetic patients, 10 age-matched controls, and 24 male medical students for correlation of carbohydrate changes with the extent of retinal, renal, and cardiovascular disease. In diabetic sera, both protein-bound sugars and free mannose, fucose, and hexosamine were significantly elevated; free galactose and inositol were elevated in some diabetic patients, and essentially undetectable in sera from controls. Serum triglycerides and pre-beta-lipoproteins were also elevated in diabetics, but alpha-lipoproteins decreased. Although no specific relationships were observed with the extent of retinal and renal disease, bivariate analyses by Pearson coefficients of correlation showed correlations between levels of serum-free mannose and systolic blood pressure, free hexosamine and duration of diabetes, and serum protein-bound fucose and age. Serum triglycerides and pre-beta-lipoprotein levels correlated with insulin therapy. These are preliminary leads of laboratory studies related to carbohydrate macromolecular changes which might aid in a better understanding of the cardiovascular complications associated with diabetes.
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
January 1958,
Acta medica Scandinavica,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
January 1985,
Journal of the Indian Medical Association,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
April 1984,
Journal of postgraduate medicine,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
December 1970,
Diabetologia,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
October 1989,
The Journal of the Association of Physicians of India,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
July 1966,
Indian heart journal,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
June 1960,
La Prensa medica mexicana,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
April 2005,
Current opinion in pharmacology,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
September 1966,
The Journal of the Association of Physicians of India,
B Radhakrishnamurthy, and
G S Berenson, and
P S Pargaonkar, and
A W Voors, and
S R Srinivasan, and
F Plavidal, and
P Dolan, and
E R Dalferes
December 1947,
Southern medicine and surgery,
