Olfactory neuroblastoma. A report of 3 cases. 2002

Theofilos Iliades, and Athanasia Printza, and Nikolaos Eleftheriades, and Kekes Georgios, and Anestis Psifidis, and Zaramboukas Thomas
AHEPA Hospital, Medical School, Aristotelian University of Thessaloniki, Greece. tiliades@med.auth.gr

Olfactory neuroblastoma is a rare malignant tumour, usually diagnosed at advanced stages. We studied 3 patients who were treated at our Institute between 1991 and 1999. One patient presented with a stage A and 2 with a stage B tumour. One patient presented with coma due to inappropriate secretion of antidiuretic hormone associated with a stage B tumour. All 3 patients were treated with complete surgical resection via a lateral rhinotomy approach and postoperative radiotherapy. There was no involvement of the cribriform plate. One patient developed a metachronous regional metastasis and was treated with neck dissection and radiotherapy. All 3 patients are free from recurrence with a follow-up period of 9 years, 18 months and 1 year, respectively. Combination therapy is the cornerstone of treatment for olfactory neuroblastoma. Complete surgical resection is the most important prognostic factor and can be accomplished via lateral rhinotomy for early stage tumours.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009296 Nasal Cavity The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA. Nasal Cavities,Cavities, Nasal,Cavity, Nasal
D009669 Nose Neoplasms Tumors or cancer of the NOSE. Cancer of Nose,Nasal Neoplasms,Nose Cancer,Cancer of the Nose,Nasal Cancer,Neoplasms, Nose,Cancer, Nasal,Cancer, Nose,Cancers, Nasal,Cancers, Nose,Nasal Cancers,Nasal Neoplasm,Neoplasm, Nasal,Neoplasm, Nose,Neoplasms, Nasal,Nose Cancers,Nose Neoplasm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D018304 Esthesioneuroblastoma, Olfactory A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33) Aesthesioneuroblastoma,Neuroblastoma, Olfactory,Olfactory Neuroblastoma,Paranasal Sinus-Nasal Cavity Esthesioneuroblastoma,Esthesioneuroblastoma,Esthesioneuroblastoma, Paranasal Sinus-Nasal Cavity,Aesthesioneuroblastomas,Esthesioneuroblastoma, Paranasal Sinus Nasal Cavity,Esthesioneuroblastomas,Esthesioneuroblastomas, Olfactory,Neuroblastomas, Olfactory,Olfactory Esthesioneuroblastoma,Olfactory Esthesioneuroblastomas,Olfactory Neuroblastomas,Paranasal Sinus Nasal Cavity Esthesioneuroblastoma

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