Ca(2+) ions enter the outer segment of rod or cone photoreceptors exclusively through the cGMP-gated channel and are extruded by the Na(+)/Ca(2+)-K(+) exchanger. Recent evidence indicates that in the plasma membrane, the Na(+)/Ca(2+)-K(+) exchanger is associated with the cGMP-gated channel. In this contribution, the possible physiologic significance of this protein complex is considered. Based on recent experimental evidence, the possibility of a direct functional interaction between the cGMP-gated channel and the Na(+)/Ca(2+)-K(+) exchanger is discussed. Furthermore, a quantitative estimation of the cytoplasmic Ca(2+) diffusion at the cGMP-gated channel indicates that Ca(2+) diffusion is largely confined to the complex of the cGMP-gated channel and the associated Na(+)/Ca(2+)-K(+) exchanger molecules.