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To investigate the effect of paraquat-induced lung damage on pulmonary absorption of drugs, rats were given a single oral dose of paraquat (250 mg/kg), and rates of drug absorption from damaged and control lungs were compared after various times. To measure absorption rates of drugs, 0.1 ml of 10 mM drug solution was administered through a tracheal cannula to anesthetized animals and, after various times, lungs were assayed for unabsorbed compound. Drugs investigated were procaine amide ethobromide, p-aminohippuric acid, and procaine amide. Rates of drug absorption increased 1.4-2.8-fold at 3.5 days after paraquat administration and returned to near control values by the 15th day. The results suggest that paraquat-induced lung damage increases the porosity of the pulmonary epithelium.
T H Gardiner, and
L S Schanker
January 1981,
Biology of the neonate,
T H Gardiner, and
L S Schanker
January 1978,
Biology of the neonate,
T H Gardiner, and
L S Schanker
January 1987,
Zeitschrift fur Erkrankungen der Atmungsorgane,
T H Gardiner, and
L S Schanker
January 1977,
Research communications in chemical pathology and pharmacology,
T H Gardiner, and
L S Schanker
May 2018,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
T H Gardiner, and
L S Schanker
July 2014,
Pharmacognosy research,
T H Gardiner, and
L S Schanker
February 1978,
Toxicology and applied pharmacology,
T H Gardiner, and
L S Schanker
March 1986,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
T H Gardiner, and
L S Schanker
November 2016,
Wei sheng yan jiu = Journal of hygiene research,
T H Gardiner, and
L S Schanker
May 1983,
The Journal of toxicological sciences,
