BIOMAT Database Logo BIOMAT Database Logo

Synthesis and antiviral activity of novel exomethylene cyclopropyl pyrimidine nucleosides. 2002

Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju 500-757, Republic of Korea.

A series of novel exomethylene cyclopropyl nucleosides have been synthesized starting from Feist's acid. Classical nucleophilic substitution conditions (K2CO3, 18-crown-6) of the tosylate 2 as well as Mitsunobu reaction (DEAD, PPh3) of alcohol 1 with pyrimidine bases afforded a series of novel cyclopropyl nucleosides. Compound 4b displayed moderate anti-HBV activity without any cytotoxicity up to 100 microM.

UI MeSH Term Description Entries
D008697 Methane The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
D011741 Pyrimidine Nucleosides Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES. Nucleosides, Pyrimidine
D006571 Heterocyclic Compounds Cyclic compounds that include atoms other than carbon in their ring structure. Heterocyclic Compound,Compound, Heterocyclic,Compounds, Heterocyclic
D006838 Hydrocarbons Organic compounds that primarily contain carbon and hydrogen atoms with the carbon atoms forming a linear or circular structure. Hydrocarbon,Saturated Hydrocarbons,Unsaturated Hydrocarbons,Hydrocarbons, Saturated,Hydrocarbons, Unsaturated
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral

Related Publications

Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of novel exomethylene cyclopropyl nucleosides.
January 2001, Nucleosides, nucleotides & nucleic acids,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides.
December 2000, Archives of pharmacal research,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral evaluation of novel exomethylene acyclic nucleosides and phosphonic acid nucleosides.
November 2005, Archiv der Pharmazie,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.
September 2003, Archives of pharmacal research,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of novel trans-2,2-dimethyl cyclopropyl nucleosides.
November 2003, Archives of pharmacal research,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral evaluation of novel cyclopropyl nucleosides, phosphonate nucleosides and phosphonic acid nucleosides.
September 2006, Archiv der Pharmazie,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Concise synthesis and antiviral activity of novel unsaturated acyclic pyrimidine nucleosides.
January 2005, Nucleosides, nucleotides & nucleic acids,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
April 2007, European journal of medicinal chemistry,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral evaluation of novel methyl branched cyclopropyl phosphonic acid nucleosides.
July 2005, Archives of pharmacal research,
Min Chul Kook, and Gu Kim, and Eun Yee Kwak, and Joon Hee Hong, and Chong Kyo Lee, and Bo Gil Choi
Synthesis and antiviral activity of 5'-O-(substituted) sulfamoyl pyrimidine nucleosides.
January 1989, Archiv der Pharmazie,
Copied contents to your clipboard!