Biomaterial Database

[Expressions of apoptosis-associated proteins in prostate carcinoma and their clinicopathological significance]. 2000

X Zhang, and F Li, and Y Jiang

Department of Pathology, First Affiliated Hospital, WCUMS, Chengdu 610041.

This study was made to explore the expressions of P53, P16, Bc1-2 and Bax protein in prostate carcinoma and their relations to histopathological grading, clinical staging and prognosis of this tumor. Immunohistochemical staining method was used to assess the expression of P53, P16, Bc1-2 and Bax protein in 51 cases of prostate carcinoma. The positive rates of P53, P16, Bc1-2 and Bax proteins were 31.37%, 54.90%, 21.57% and 74.51% respectively. The expression of P53 and Bc1-2 showed positive correlation with the histopathological grading and clinical staging of this tumor (P < 0.05). However, the expression of P16 and Bax showed negative correlation with the grading and staging of the tumor (P < 0.05). The expression of P53 protein correlated with the survival rate of these patients. There was a relation between P53 and Bc1-2, and a relation between Bc1-2 and Bax also (P < 0.05). These findings suggest that expressions of P53, P16, Bc1-2 and Bax may be helpful to the grading, staging and prognostic evaluation of prostate carcinoma.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011471	Prostatic Neoplasms	Tumors or cancer of the PROSTATE.	Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D011518	Proto-Oncogene Proteins	Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.	Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old