Biomaterial Database

[Effect of peritonitis pathomorphology on rabbit model in peritoneal dialysis]. 2001

X M Zhang, and Y H Liu, and Q C Liang

Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

The study about peritonitis rabbit model is rarely, although peritonitis have been considered mainly complication in peritoneal dialysis. Twelve New Zealand rabbit were divided into peritonitis group and control group. The peritonitis group rabbit were injected with the dialysate containing alive staphylococcus aureus and the control ones with 0.9% saline into the peritoneum. The pathomorphology changes of the peritonitis were observed. The results showed (1) There was proliferation and swollen of mesothelial cells, vessel dilation and infiltration of inflammation cells in the peritoneum in the peritonitis group; and no such changes in the control group. (2) The D/D0 glucose concentration in the dialysate of peritonitis group was lower than that of the control ones at any point except the 0 min (P < 0.01). (3) The ratio of Cr concentration in the dialysate to Cr concentration in the plasma in the peritnitis group was significantly higher than that of the control group (P < 0.05). (4) The WBC count in the dialysate of peritonitis group was obviously higher than that of the control group all points except 0. These results implied that after injection of alive staphylococcus aureus to the peritoneal cavity of New Zealand rabbit for 48 hours, the pathomorphology change was similar with the characteristics of peritonitis complicated with peritoneal dialysis in patient.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010530	Peritoneal Dialysis	Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.	Dialyses, Peritoneal,Dialysis, Peritoneal,Peritoneal Dialyses
D010537	Peritoneum	A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.	Parietal Peritoneum,Peritoneum, Parietal,Peritoneum, Visceral,Visceral Peritoneum,Parametrium,Parametriums
D010538	Peritonitis	INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	Primary Peritonitis,Secondary Peritonitis,Peritonitis, Primary,Peritonitis, Secondary
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia