BIOMAT Database Logo BIOMAT Database Logo

Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. 2003

Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. bgood@pitt.edu

OBJECTIVE We examined whether regional adipose tissue distribution, specifically that of skeletal muscle fat and visceral abdominal fat aggregation, is characteristic of elderly individuals with hyperinsulinemia, type 2 diabetes, and impaired glucose tolerance (IGT). METHODS A total of 2,964 elderly men and women (mean age 73.6 years) were recruited for cross-sectional comparisons of diabetes or glucose tolerance, generalized obesity with dual-energy X-ray absorptiometry, and regional body fat distribution with computed tomography. RESULTS-Approximately one-third of men with type 2 diabetes and less than half of women with type 2 diabetes were obese (BMI > or =30 kg/m(2)). Despite similar amounts of subcutaneous thigh fat, intermuscular fat was higher in subjects with type 2 diabetes and IGT than in subjects with normal glucose tolerance (NGT) (11.2 +/- 9.4, 10.3 +/- 5.8, and 9.2 +/- 5.9 cm(2) for men; 12.1 +/- 6.1, 10.9 +/- 6.5, and 9.4 +/- 5.3 cm(2) for women; both P < 0.0001). Visceral abdominal fat was also higher in men and women with type 2 diabetes and IGT than in subjects with NGT (172 +/- 79, 163 +/- 72, and 145 +/- 66 cm(2) for men; 162 +/- 66, 141 +/- 60, and 116 +/- 54 cm(2) for women; both P < 0.0001 across groups). Higher rates of intermuscular fat and visceral abdominal fat were associated with higher fasting insulin in normal-weight (BMI <25 kg/m(2)) men (r = 0.24 for intermuscular fat, r = 0.37 for visceral abdominal fat, both P < 0.0001) and women (r = 0.20 for intermuscular fat, r = 0.40 for visceral abdominal fat, both P < 0.0001). These associations were not found in obese subjects. CONCLUSIONS Elderly men and women with normal body weight may be at risk for metabolic abnormalities, including type 2 diabetes, if they possess an inordinate amount of muscle fat or visceral abdominal fat.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008297 Male Males
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005215 Fasting Abstaining from FOOD. Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000005 Abdomen That portion of the body that lies between the THORAX and the PELVIS. Abdomens
D000273 Adipose Tissue Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white. Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women.
June 2004, Journal of internal medicine,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women.
March 1989, Diabetes,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Visceral adipose tissue accumulation and cardiovascular disease risk profile in postmenopausal women with impaired glucose tolerance or type 2 diabetes.
March 2011, Clinical endocrinology,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
[Type 2 diabetes and impaired glucose tolerance].
February 2013, Nihon rinsho. Japanese journal of clinical medicine,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men.
January 1999, Annals of internal medicine,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Association of sleep duration with type 2 diabetes and impaired glucose tolerance.
November 2007, Diabetologia,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Distribution of adipose tissue and risk of impaired glucose tolerance in pregnancy.
January 1985, British medical journal (Clinical research ed.),
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function.
November 2004, Journal of clinical and experimental neuropsychology,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.
November 2023, medRxiv : the preprint server for health sciences,
Bret H Goodpaster, and Shanthi Krishnaswami, and Helaine Resnick, and David E Kelley, and Catherine Haggerty, and Tamara B Harris, and Ann V Schwartz, and Steven Kritchevsky, and Anne B Newman
Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.
June 2024, Obesity (Silver Spring, Md.),
Copied contents to your clipboard!