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In 154 patients with phenacetin nephropathy and in 26 patients with phenacetin abuse but without nephropathy a laxative abuse was observed in 3.2% and 15.4%, hypokalemia (3.5 maequ/l or less) in 9.1% and 3.9, respectively. The mean plasma potassium concentration was normal in both groups (4.45 and 4.22 maequ/l, respectively). These data do not support the recently proposed hypothesis that the simultaneous abuse of laxatives contributes to the development of analgesic nephropathy, and that the absence of laxative intake might explain the lack of renal damage in some phenacetin abusers. Although it cannot be excluded that long-standing potassium deficiency in consequence of an abuse of laxatives or diuretics exerts an additional nephrotoxic effect in some cases, this mechanism seems not to be involved in the majority of patients with phenacetin nephropathy.
K D Bock, and
T Nitzsche
November 1958,
Lyon medical,
K D Bock, and
T Nitzsche
August 1961,
Canadian Medical Association journal,
K D Bock, and
T Nitzsche
October 1979,
Medicina clinica,
K D Bock, and
T Nitzsche
April 1958,
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften,
K D Bock, and
T Nitzsche
May 1962,
Munchener medizinische Wochenschrift (1950),
K D Bock, and
T Nitzsche
January 1981,
Revue medicale de Bruxelles,
K D Bock, and
T Nitzsche
June 1975,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
K D Bock, and
T Nitzsche
December 1975,
MMW, Munchener medizinische Wochenschrift,
K D Bock, and
T Nitzsche
January 1974,
Ergebnisse der inneren Medizin und Kinderheilkunde,
K D Bock, and
T Nitzsche
May 1958,
Schweizerische medizinische Wochenschrift,
